22HLT06
GenomeMET
Metrology for genomic profiling to support early cancer detection and precision medicine
The project 22HLT06 GenomeMET has received funding from the European Partnership on Metrology, co-financed by the European Union’s Horizon Europe Research and Innovation Programme and by the Participating States.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or EURAMET. Neither the European Union nor the granting authority can be held responsible for them.
The Project
GenomeMET Work Packages
The GenomeMET project is structured into the following 6 Work Packages:
Develop Reference Material (RM) and EQA material alongside SI-traceable characterisation frameworks to aid genomic RMS development and support EQA schemes.
Develop Reference Measurement Systems (RMS) for validating and ensuring the quality assurance (QA) of genomic profiling IVDs.
Identify main uncertainty drivers in genomic profiling workflows and develop statistical approaches for assessing measurement uncertainty and examination uncertainty in multiparametric genomic profiles.
Facilitating impactful dissemination, communication, and exploitation of project outcomes to standardise and implement genomic biomarker profiling across Europe.
Ensuring effective project management, coordination, and compliance with all regulatory and ethical standards.
Create Reference Measurement Procedures (RMP) and higher-order methods to support the development of genomic RMS.
News Updates
22nd Febuary 2024
In the of a rising global cancer crisis, with a death toll of 1.3 million1 in 2020 and anticipated 32% increase in cases by 204- in Europe, the accurate profiling of cancer's genetic make up is acritical tool in its treatment
Pioneering Cancer Treatments through Enhanced Genomic Profiling in the GenomeMET Project
4th June 2025
We are excited to announce that our project partner, Marco Lo Iacono from UNITO, recently had the opportunity to present a key component of our collaborative project during the ddPCR World 2025 On Tour. This prestigious event brought together industry leaders and innovators, providing a platform for sharing insights and advancements in the field.
GenomeMET Partner showcases the latest development on a potential new reference material for circulating tumor cells CTCs analysis
June 2025
Check out the newly published third summary of our project! Discover key findings and the significant impact of our work. Don't miss out on the insights that could inspire your next project! Read the full summary now and join us in exploring new possibilities.
Highlights from Our Latest Project Summary
July 2025
At the Summer School of Metrology, themed FUTURE NEEDS FOR METROLOGY: CLIMATE SCIENCE, QUANTUM TECHNOLOGIES AND THE DIGITAL TRANSFORMATION, Dr. Carla Divieto presented the GenomeMET project during her talk on Metrology in medicine and biology: underpinning clinical decisions for patient safety in the session focused on Metrology for the quality of life and climate science. She highlighted the crucial role of metrology in advancing precision medicine and early cancer detection.
For more details, check this link out!
Presentation at Summer School of Metrology - Varenna
October 2025
This study introduces a five-gene multiplex dPCR reference panel showing impressive linearity and precision across synthetic and genomic DNA
Check out our latest study: Multiplexed Digital PCR Reference Gene Measurement for Genomic and Cell-Free DNA Analysis.
Why does it matter? This method enhances total DNA quantification, essential for precision medicine, NGS library preparations, and copy number variation analysis.
October 2025
Help Us Improve: Participate in Our Survey!
Deadline extended to 31/12/2025, don't miss your chance to share your thoughts!
We value your input! As part of our ongoing commitment to enhance our project, we invite you to participate in our short survey on NGS traceability. Your feedback will be instrumental in guiding our next steps.
Please complete the survey by December 31 to ensure your feedback is considered.
Click here to take the survey!
13-15 October 2025
We are thrilled to share the insights from the recent ISOBM Conference held in Murnau (Germany). Our partners from the GenomeMET project, Dr. Alison Denvonshire (NML at LGC), Dr. Jenni Farley (GenQA) and Dr. Marcel Kremser (INSTAND) presented compelling perspectives on genomic profiling standardisation strategies and EQA for liquid biopsy showcasing two new schemes.
Exciting News From the ISOBM Conference Featuring Our GenomeMET Partners
21st November 2025
We are proud to share insights from the IFCC Committee on Molecular Diagnostics (C-MDO) sponsored 3rd International Forum on Clinical Molecular Diagnostics meeting, which took place in a hybrid format in Nanjing, China. Dr. Carole Foy from NML, UK was invited to give a lecture on behalf of the GenomeMET consortium. She highlighted the vital role of establishing standards in cancer genomic profiling, showcasing the GenomeMET's ambitious goals and innovative approaches to ensure reliable and beneficial outcomes for patient care.
Highlights from IFCC C-MDO meeting in China.
January 2026
We are pleased to share our new paper in Biological Procedures Online, presenting a candidate Reference Measurement Procedure for MET CNV quantification using digital PCR, aimed at improving standardization, SI traceability, and inter-laboratoy comparability in precision oncology.
Check out our latest study:
New candidate Reference Measurement Procedure for MET CNV detection and quantification using digital PCR.
May 5, 2026
We are excited to announce an upcoming workshop designed specifically for Stakeholders in the field of cancer diagnostics. This interactive session aims to foster collaboration, share insights, and enhance our collective approach toward standardization and quality control in cancer DNA diagnostics.
Click here to find out more!
Join our online workshop:
Standardization of Methods, Pre-Analythics, and Quality Control for Cancer DNA Diagnostics.
March 2026
Missed our recent Genomeweb webinar on advancing traceability and comparability in clinical diagnostics?
Experts from the UK National Measurement Laboratory at LGC shared GenomeMET-driven approaches to improve standardization, traceability, and confidence in solid tumor and liquid biopsy genomic testing.
Watch the full recording here:
https://event.on24.com/wcc/r/5278395/13BF7A3F179EDE1804909B2644155F63?partnerref=lgcod
From Measurement to Medicine: How GenomeMET Supports Reliable Genomic Testing
08-11 June, 2026
The GenomeMET consortium is pleased to share that Dr. Jessica Petiti from INRiM (Istituto Nazionale di Ricerca Metrologica) presented her research at the EACR 2026 Congress: Innovative Cancer Science in Budapest, Hungary.
GenomeMET Results at EACR 2026
Her work entitled "Metrologically Traceable Quantification of NRAS p.Q61R by Digital PCR," presents a validated dPCR-based method for the accurate quantification of the clinically relevant NRAS p.Q61R mutation, supporting harmonized molecular measurements and reliable biomarker assessment in precision oncology.
We congratulate Dr. Petiti and all contributing partners on this achievement and their valuable contribution to the GenomeMET project.
June 2026
Call for Participants: Survey on Quantitative Measurements in Bioanalysis
The CCQM Task Group for Terms, Quantities and Units for Bioanalytical Measurement invites participants to complete the following questionnaires about quantitative measurements in:
(1) DNA and RNA analysis using methods such as, but not limited to, qPCR and Next Generation Sequencing;
(2) the analysis of whole entities/cells using methods such as, but not limited to, flow cytometry and cell counting;
(3) protein analysis using methods such as, but not limited to, mass spectrometry and qNMR.
Click the following links to take the surveys, it will take you only a few minutes:
(2) Measurement of cells and subcellular particles
Please complete the survey by June 30 to ensure your feedback is considered!
24-26 June, 2026
At BIOTECH2026 – Frontiers in Italian Biotechnology in Verona, Aurora Schiavon from University of Torino, presented her latest work on Circulating Tumore Cells (CTC) mutational profiling using Parsortix® enrichment and ddPCR, supporting the development of standardized reference materials for liquid biopsy applications.
How can we improve the reliability and reproducibility of liquid biopsy testing?
Her results highlight the potential of an in-cassette lysis workflow for reliable mutation detection in CTC, contributing to improved analytical standardization for future clinical and research applications.
This work is part of the GenomeMET European project, advancing metrology for genomic profiling in early cancer detection and precision medicine.
10-13 August, 2026
GenomeMET partners attended the first EURAMET Summer School on Biochemical Metrology in Kloster Drübeck, Germany, bringing together early-career researchers, metrologists, and experts from across Europe to strengthen the foundations of measurement science in the life sciences.
Presenting at the first EURAMET Summer School on biochemical metrology
Colleagues from National Institute of Biology (NIB) and the UK National Measurement Laboratory (NML) at LGC presented advances from the GenomeMET project, highlighting the role of metrology in supporting reliable and comparable genomic profiling for cancer diagnostics and precision medicine
Past Events
- 5 May 2026
- 15 to 16 December 2025, online
- 27th September 2023
- 11 to 12 February 2025
- 23 to 24 May 2024