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GenomeMET Work Package 2

Work Package | 2

Reference Measurement Procedures and higher-order methods to support genomic Reference Measurement Systems development

Aims

  • to develop and evaluate nucleic acid amplification-based measurement procedures for key cancer biomarkers

  • to develop and evaluate methods for the quantification of total DNA and quantification of DNA molecules of specified fragment size range or quality which would be suitable for value assignment of calibrators for end-user methods

  • to apply sequencing technologies and methods as Reference Measurement Procedures approaches for sequence identity

  • to establish the reproducibility of candidate Reference Measurement Procedures and review the adequacy of Measurement Uncertainty estimation

Work packages

Reference Measurement Systems to support validation and quality assurance of genomic profiling IVDs

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Creating impact

Reference Measurement Procedures and higher order methods to support genomic Reference Measurement Systems development

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Management & coordination

Reference Material and External Quality Assessment material development and SI-traceable characterisation frameworks to support genomic Reference Measurement Systems development and External Quality Assessment schemes

Measurement uncertainty frameworks to support genomic reference measurement systems

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